The possibility of estimating the minimum total flow in a cascade with concentrations of a target component given in the product and waste flows by means of a model match abundance ratio cascade (MARC) is studied. The parameters required to describe MARC characteristics are the total number of separation stages, the feed flow location, and the M* parameter, which is equal to a half-sum of mass numbers of the target and the supporting components. Specific research carried out independently in two scientific labs in China and Russia has demonstrated that the integral parameters of the MARC, optimized by the M* parameter, are very close to that of the optimum by the minimum total flow cascade found by means of numerical optimization. The calculation is performed for separation of krypton isotopes when the end component 78Kr and the intermediate component 83Kr are considered to be the targets. It paves the way to use the optimized MARC parameters for two purposes: first, for fast and easy evaluation of the real cascade parameters and second, as an initial guess in its further direct numerical optimization, thereby allowing significant savings in computation time.