The enthalpies of solution of ordinary (H2O) and heavy (D2O) water in nitromethane (NM) acetomtnle (ACN) and propylene carbonate (PC) were measured calorimetrically at 298 15 K Standard (at the infinite dilution) enthalpies of solution and solvation along with D2O-H2O solute isotope effects on the quantities in question were calculated The enthalpies of solution of water H/D isotopologues were found to be positive by sign and substantially increasing in magnitude on going from ACN and PC to NM whereas the corresponding positive solute H/D Isotope effect changes in a consequence NM > ACN > PC The qualitative interrelations between the enthalpy-isotopic effect of dissolution (solvation) of water and the electron-accepting/donating ability of aprotic dipolar solvent (within a series considered) were found (C) 2010 Elsevier B V All rights reserved