We present the first piezoelectric triggered mechanical-electronic logic operation using the piezotronic effect, through which the integrated mechanical actuation and electronic logic computation are achieved using only ZnO nanowires (NWs). By utilizing the piezoelectric potential created in a ZnO NW under externally applied deformation, strain-gated transistors (SGTs) have been fabricated. Using the SGTs as building blocks, universal logic components such as inverters, NAND, NOR, and XOR gates have been demonstrated for performing piezotronic logic calculations.