Catalytic systems based on mixed oxides catalysts derived from a series of hydrotalcite-like compounds through the coprecipitation method were investigated for hydrolysis of carbonyl sulfide (COS) in a fixed-bed reactor. The effects of pH, temperature of synthesis and hydrothermal treatment on catalytic activity were studied. Furthermore, the samples were characterized by pH titration, X-ray diffraction (XRD) and Brunauer-Emmett-Teller method (BET). The results showed that the catalysts could be prepared by precipitating solution of (Co + Ni)/Al at pH 9.0, synthetic temperature at 25 degrees C, and then hydrothermal treatment at 50 degrees C for 12 h. The XRD patterns showed the precursors had typical hydrotalcite structure and the catalysts were mixed oxides. All catalysts could be considered mesoporous. (C) 2010 Elsevier B.V. All rights reserved.