Drug Release from Nanoparticles of Poly(DL-lactide-co-glycolide)

Jae-Woon Nah; Young-Il Jeong; Jae-Joon Koh

Korean Journal of Chemical Engineering, Vol.17, No.2, 230-236, March, 2000

DOI10.1007/BF02707148 Export Citation

Drug Release from Nanoparticles of Poly(DL-lactide-co-glycolide)

Jae-Woon Nah^†, Young-Il Jeong¹, and Jae-Joon Koh²

Department of Polymer Science and Engineering, Sunchon National University, Chonnam 540-742, Korea
¹Department of Pharmaceutics and Pharmacokinetics, Kyoto Pharmaceutical University, Yamashina-Ku, Kyoto 607-8414, Japan
²Department of Internal Medicine, Seoul Municipal Boramae Hospital, Seoul National University, Seoul 156-707, Japan

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Nanoparticles of Poly(DL-lactide-co-glycolide) (PLGA) were prepared by dialysis method without surfactant. The size of PLGA nanoparticles prepared from dimethylacetamide (DMAc), dimethylformamide (DMF), and dimethylsulfoxide (DMSO) as an initial solvent was smaller than that of acetone or 1,4-dioxane. Selected initial solvent used to dissolve the copolymer significantly affects the size of nanoparticles. Also, the size of PLGA nanoparticles was changed according to the copolymer composition. It was shown that PLGA nanoparticles have spherical shpaes from the results of scanning electron microscope (SEM) and transmission electron microscope (TEM) observations. From these results was shown the potential that the PLGA nanoparticles could be formed successively by dialysis method without surfactant. The drug-loading contents were also dependent on the copolymer composition and initial feeding amount of the drug. The greater lactide ration on the copolymer composition led to higher drug loading contents. Also, the higher the initial feeding amount of drug, the higher the drug loadging contents. Clonazepam (CNZ) was used as a model drug. CNZ was slowy released in higher lactide ratio in the copolymer composition and in the higher drug loading contents.

Keywords:Poly(DL-lactide-co-glycolide);Nanoparticles;Dialysis Method;Clonazepam;Controlled Drug Release

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[1] Alleman E, Eur. J. Pharm. Biopharm., 39, 173 (1993)

[2] Cho CS, Na JW, Jeong YI, Kim SH, Lee YM, Sung YK, Polym.(Korea), 19(6), 926 (1995)

[3] Ciftci K, Int. J. Pharm., 131, 73 (1996)

[4] Couvreur P, Pharm. Res., 8, 1079 (1991)

[5] Couvreur P, J. Control. Release, 19, 259 (1992)

[6] Davis SS, Pharmaceut. Technol., 5, 71 (1981)

[7] Kreuter J, J. Control. Release, 16, 169 (1991)

[8] Davis SS, J. Control. Release, 24, 157 (1993)

[9] Dunn SE, Pharm. Res., 11, 1016 (1994)

[10] Govender T, J. Control. Release, 57, 171 (1999)

[11] Gref R, Science, 263, 1600 (1994)

[12] Illum L, Int. J. Pharm., 12, 135 (1982)

[13] Illum L, Int. J. Pharm., 29, 53 (1986)

[14] Jeffery H, Int. J. Pharm., 77, 169 (1991)

[15] Jeong YI, J. Control. Release, 51, 169 (1998)

[16] Juliene MC, Drug Dev. Ind. Pharm., 18, 1063 (1992)

[17] Kwon GS, Pharm. Res., 12, 192 (1995)

[18] Lasic DD, Nature, 355, 279 (1992)

[19] Leroux JC, J. Control. Release, 39, 339 (1996)

[20] Muller RH, J. Control. Release, 20, 237 (1992)

[21] Mura P, Pharm. Acta Helv., 65, 298 (1990)

[22] Nah JW, Jeong YI, Cho CS, J. Polym. Sci. B: Polym. Phys., 36(3), 415 (1998)

[23] Peracchia MT, J. Control. Release, 46, 223 (1997)

[24] Scholes PD, J. Control. Release, 25, 145 (1993)

[25] Seijo B, Int. J. Pharm., 62, 1 (1990)

[26] Shin IG, J. Control. Release, 51, 1 (1998)

[27] Sjostrom B, J. Pharm. Sci., 82, 585 (1993)

[28] Sjostrom B, Pharm. Res., 12, 39 (1995)

[29] Sjostrom B, J. Pharm. Sci., 82, 579 (1993)

[30] White HS, "Antiepileptic Drugs," In The Science and Practice of Pharmacy, Remingtion, Vol. 2, 19th ed.; A.R. Gennaro, Eds.; Mack Publishing Co.: Easton, Pennsylvania, USA, 1173 (1995)

[31] Venier-Julienne MC, Pharm. Acta Helv., 71, 121 (1996)

[32] Witschi C, Eur. J. Pharm. Biopharm., 43, 215 (1997)

[33] Yoshioka T, Int. J. Pharm., 81, 131 (1981)

[34] Zhang X, Int. J. Pharm., 132, 195 (1996)