Dissolution is not the only but a major issue in the design of pharmaceutical products. The technological tasks differ depending on the properties of the active pharmaceutical ingredient and the therapeutic goal. Three extrusion techniques, wet extrusion, solid lipid extrusion and melt extrusion, are introduced and their potential and limits with respect to dissolution profiles are described. The most flexible design of dissolution profiles can be achieved by melt extrusion. Depending on the selected matrix material and the process parameters all types of dissolution profiles can be achieved.