Enantioselective synthesis has been achieved using chiral compounds arising from mono- and dideuterated methyl groups as chiral inducers in conjunction with asymmetric autocatalysis. The absolute configuration of the product was controlled by the small degree of chirality generated by the difference between the partially deuterated methyl groups (CDH2 and CD2H) and the non-deuterated methyl group (CH3) in N-benzoyl-alpha-methylalanine.