화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.36, No.1, 1-8, January, 2012
Export Citation
초임계 유체를 이용한 PLGA 입자 제조에 첨가제가 미치는 영향
Effect of an Excipient on the Formation of PLGA Particles Using Supercritical Fluid
정인일, 함승주, 임교빈1, 유종훈1, †
  • 연세대학교 화공생명공학과
  • 1수원대학교 화학공학과
In-Il Jung, Seungjoo Haam, Giobin Lim1, and Jong-Hoon Ryu1, †
  • Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Korea
  • 1Department of Chemical Engineering, The University of Suwon, Gyeonggi-do 445-743, Korea
E-mail:
초록
본 연구에서는 초임계 aerosol solvent extraction system(ASES) 공정을 이용하여 poly(lactic-co-glycolic acid)(PLGA) 미립자를 제조하기 위해 첨가제로 hydroxypropyl-β-cyclodextrin (HP-β-CD)를 사용하였으며, HP-β-CD의 첨가량이 PLGA 입자의 형상에 미치는 영향을 조사하였다. 또한 항암제인 파클리탁셀이 봉입된 미립자를 제조하여 HP-β-CD의 함량에 따른 약물 방출 특성의 변화를 고찰하였다. PLGA(75:25)의 경우 HP-β-CD를 고분자 중량대비 약 40%까지, PLGA(50:50)의 경우 약 30%까지 첨가하였을 때 미립자가 형성되었으며, HP-β-CD의 첨가량이 이보다 더 적은 경우에는 PLGA가 필름 형태로 형성되었다. 파클리탁셀이 봉입된 PLGA/HP-β-CD 미립자의 경우 HP-β-CD의 함량이 증가함에 따라 더 빠른 속도로 약물이 방출됨을 확인할 수 있었다.
In this study, we employed hydroxypropyl-β-cyclodextrin (HP-β-CD) as an excipient to produce poly(lactic-co-glycolic acid) (PLGA) fine particles by a supercritical fluid process, called aerosol solvent extraction system (ASES), and investigated the effect of HP-β-CD content on the morphology of the particles. The influence of HP-β-CD on the drug release characteristics of paclitaxel-loaded PLGA particles was also evaluated. Fine particles were obtained when the HP-β-CD content in PLGA/HP-β-CD mixtures was greater than 40% and 30%, respectively, for PLGA(75:25) and PLGA(50:50), whereas a film-like precipitate was obtained for lower HP-β-CD content. The release rate for paclitaxel loaded PLGA(75:25)/HP-β-CD particles was found to increase with HP-β-CD content.
Keywords:supercritical fluid;PLGA;cyclodextrin;fine particles;paclitaxel.
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