A highly sensitive method was investigated for the simultaneous determination of acetaminophen (AC) and dopamine (DA) using single wall carbon nanotubes modified carbon-ceramic electrode (SWCNT/CCE). The SWCNT/CCE displayed excellent electrochemical catalytic activities towards the oxidation of AC and DA. Under optimized experimental conditions in differential pulse voltammetry technique. AC and DA gave linear response over the ranges 0.2-100.0 mu M (R-2 = 0.996) and 0.4-150.0 mu M (R-2 = 0.999), respectively. The detection limits (S/N = 3) were found to be 0.12 mu M for AC and 0.22 mu M for DA. The present method was applied to the determination of AC and DA in some commercial pharmaceutical samples. (C) 2010 Elsevier Ltd. All rights reserved.