Heat activated cooling has the potential of utilizing thermal sources that currently go unused such as engine exhaust heat or industrial waste heat. Using these heat sources can provide enhanced energy utilization and reduced fuel usage in applications where cooling is needed. The concept developed here uses waste heat from stationary and mobile engine cycles to generate cooling for structures and vehicles. It combines an organic Rankine cycle (ORC) with a conventional vapor compression cycle. A nominal 5 kW cooling capacity prototype system was developed based on this concept and tested under laboratory conditions. In order to maintain high system performance while reducing size and weight for portable applications, microchannel based heat transfer components and scroll based expansion and compression were used. Although the system was tested off of its design point, it performed well achieving 4.4 kW of cooling at a measured heat activated COP of 0.48. Both the conversion and 2nd law efficiencies were close to the model results, proving it to be an attractive technology. The measured isentropic efficiency of the scroll expander reached 84%, when the pressure ratio was close to the scroll intrinsic expansion ratio. The reduced cooling capacity was attributed to off design operation. (C) 2010 Elsevier Ltd. All rights reserved.