As states in the U.S. adopt new energy codes, it is important to understand the benefits for each state and its building owners. This paper estimates life-cycle energy savings, carbon emission reduction, and cost-effectiveness of conventional energy efficiency measures in new commercial buildings using an integrated design approach. Results are based on 8208 energy simulations for 12 prototypical buildings in 228 cities, with 3 building designs evaluated for each building-location combination. Results are represented by easy-to-understand mappings that allow for regional and state comparisons. The results show that the use of conventional energy efficiency technologies in an integrated design framework can decrease energy use by 15-20% on average in new commercial buildings, and over 35% for some building types and locations. These energy reductions can often be accomplished at negative incremental life-cycle costs and reduce a building's energy-related carbon footprint by 9-33%. However, generalizing these results on energy use, life-cycle costs, and carbon emissions misses exceptions in the results that show the importance of location-specific characteristics. Also, states do not appear to base energy code adoption decisions on either potential energy savings or life-cycle cost savings. Published by Elsevier B.V.