Annual primary energy use in a central module of an office building consisting of two offices separated with a corridor was estimated by means of dynamic computer simulations. The simulations were conducted for conventional all-air VAV ventilation system and thermo active building system (TABS) supplemented with CAV ventilation. Simulations comprised moderate, hot-dry and hot-humid climate. Heavy and light wall construction and two orientations of the building (east-west and north-south) were considered. Besides the energy use, also capability of examined systems to keep a certain level of thermal comfort was examined. The results showed that with the moderate climate, the TABS decreased the primary energy use by about 16% as compared with the VAV. With hot-humid climate, the portion of the primary energy saved by TABS was ca. 50% even with the supply air dehumidification taken into account. The TABS working in a moderate climate kept the predicted percentage of dissatisfied (PPD) <10% during 60-80% of the working hours per year. Optimization of the TABS's control strategy (circulation pump dead-band, water supply temperature) resulted in significant reduction of the annual working hours with PPD > 10%; 1.4% in comparison to 17.5% h/yr. The highest estimated loss of occupants' productivity related to their thermal sensation hasn't exceeded 1% in whole year average. (C) 2011 Elsevier B.V. All rights reserved.