A new fluoride mediated synthesis of mesoporous silica and their usefulness in controlled delivery of duloxetine hydrochloride a serotonin re-uptake inhibitor

Mani Ganesh; Pushparaj Hemalatha; Peng Mei Mei; Krishnan Rajasekar; Hyun Tae Jang

Journal of Industrial and Engineering Chemistry, Vol.18, No.2, 684-689, March, 2012

DOI10.1016/j.jiec.2011.11.121 Export Citation

A new fluoride mediated synthesis of mesoporous silica and their usefulness in controlled delivery of duloxetine hydrochloride a serotonin re-uptake inhibitor

Mani Ganesh^{1, 2}, Pushparaj Hemalatha¹, Peng Mei Mei¹, Krishnan Rajasekar^{2, †}, and Hyun Tae Jang^{1, †}

¹Department of Chemical Engineering, Hanseo University, 360 Daegok-ri, Haemi-myun, Seosan-si 356 706, Chungcheongnam-do, South Korea
²Department of Nano Technology, Biotechnology Centre, Anna University of Technology, Jothipuram, Coimbatore 641047, Tami Nadu, India

E-mail:,

A new type of mesoporous silica nanoparticle (MSN) was synthesized in fluoride media via sol-gel technique using TritonX 100 and Tween-20. The surface area and pore volume of the MSN particles were modified by varying the concentration of Tween-20. The prepared MSN nanoparticles with large surface area and pore volume (T-2, T-3) were selected to accommodate the model drug duloxetine hydrochloride (DX) for evaluation of their drug-loading and release abilities. Calcined and DX loaded nanoparticles were characterized by Brunauer-Emmett-Teller technique (BET), powder X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric (TG) analysis and UV-diffuse reflectance (UVDRS). In vitro release studies proved that the particle displays an initial burst release followed by sustained release for up to 140 h. From the studies it is evident that the synthesized particle may be useful as a carrier for sustained release of active pharmaceutical ingredients (APIs).

Keywords:Mesoporous silica;TritonX100;Tween20;Duloxetine;In vitro release

[References]

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[Referenced By]

[1] Beck JS, Vartuli JC, Roth WJ, Leonowicz ME, Kresge CT, Schmitt KD, Chu CTW, Olsen DH, Sheppard EW, McCullen SB, Higgins JB, Schlenker JLJ, J. Am.Chem. Soc., 114, 10834 (1992)

[2] Kresge CT, Leonowicz ME, Roth WJ, Vartuli JC, Beck JS, Nature., 359, 710 (1992)

[3] Vallet-Regi M, Ramila A, Del Real RP, Perez-Pariente J, Chem. Mater., 13, 308 (2001)

[4] Liong M, Lu J, Kovochich M, Xia T, Ruehm SG, Nel AE, Tamanoi F, Zink JI, ACS Nano., 2, 889 (2008)

[5] Wen LX, Ding HM, Wang JX, Chen JF, J. Nanosci. Nanotechnol., 9-10, 3139 (2006)

[6] Slowing II, Vivero-Escoto JL, Wu CW, Lin VS, Adv. Drug Deliv. Rev., 60, 1278 (2008)

[7] Yang P, Quan Z, Lu L, Huang S, Lin J, Fu H, Nanotechnology., 18, 235703 (2007)

[8] Lee K, Lee D, Lee H, Kim CK, Wu Z, Lee K, Korean J. Chem. Eng., 27(4), 1333 (2010)

[9] Qu F, Zhu G, Huang S, Li S, Zhang JSD, Qiu S, Microporous Mesoporous Mater., 92, 1 (2006)

[10] Heikkila¨ T, Salonen J, Tuura J, Kumar N, Salmi T, Murzin DY, Hamdy MS, Mul G, Laitinen L, Kaukonen AM, Hirvonen J, Lehto VP, Drug Deliv., 14, 337 (2007)

[11] Kortesuo P, Ahola M, Karlsson S, Kangasniemi I, Yli-Urpo A, Kiesvaara J, Biotechnol., 21, 193 (1999)

[12] Colilla M, Manzano M, Vallet-Regi M, Int. J. Nanomed., 3, 403 (2008)

[13] Yanagisawa T, Shimizu T, Kuroda K, Kato C, Bull. Chem. Soc. Jpn., 63, 988 (1990)

[14] Zhao DY, Feng JL, Huo QS, Melosh N, Fredrickson GH, Chmelka BF, Stucky GD, Science, 279(5350), 548 (1998)

[15] Hodgkins RP, Garcia-Bennett AE, Wright PA, Microporous Mesoporous Mater., 79, 241 (2005)

[16] Fan J, Yu C, Gao F, Lei J, Tian B, Wang L, Luo Q, Tu B, Zhou W, Zhao D, Angew.Chem. Int. Ed., 42, 3146 (2003)

[17] Chen CY, Burkett SL, Li HX, Davis ME, Microporous Mater., 2, 27 (1993)

[18] Huo Q, Margolese DI, Ciesla U, Demuth DG, Feng P, Gier TE, Sieger P, Firouzi A, Chmelka BF, Chem. Mater., 6, 1176 (1994)

[19] Ogawa M, J. Am. Chem. Soc., 116(17), 7941 (1994)

[20] Attard GS, Glyde JC, Goltner CG, Nature, 378(6555), 366 (1995)

[21] Brinker CJ, Lu YF, Sellinger A, Fan HY, Adv. Mater., 11(7), 579 (1999)

[22] Doshi DA, Gibaud A, Goletto V, Lu MC, Gerung H, Ocko B, Han SM, Brinker CJ, J. Am. Chem. Soc., 125(38), 11646 (2003)

[23] Lu YF, Ganguli R, Drewien CA, Anderson MT, Brinker CJ, Gong WL, Guo YX, Soyez H, Dunn B, Huang MH, Zink JI, Nature, 389(6649), 364 (1997)

[24] Sweetman SC, Martindale, the Complete Drug Reference, 34th ed., Pharmaceutical Press, London (2005)

[25] Brunton LL, Parker KS, Lazo JS, Goodman and Gillman’s, The Pharmacological Basis of Therapeutics, 11th ed., McGraw Hill Publishing, London (2005)

[26] Hunziker MM, Suehs BT, Bettinger TL, Crisrnon ML, Clin. Ther., 27, 1126 (2005)

[27] Anders DW, Jon G, Robert H, Am. J. Health. Syst. Pharm., 62, 2481 (2005)

[28] Kolatkar G, Zisman E, US 0292511A1 (2007)

[29] Prasad, Rudresha, Korlakunte, Virupakshaiah, WO 034503 (2007)

[30] Yunoos M, Gowri Sankar D, Pragati Kumar B, Hameed S, Hussain AE, E-J. Chem., 7, 785 (2010)

[31] Charnay C, Begu S, Tourne-Peteilh C, Nicole L, Lerner DA, Devoisselle JM, Eur. J. Pharm. Biopharm., 57, 533 (2004)

[32] Xia W, Chang J, J. Control. Release., 110, 522 (2006)

[33] Nunes CD, Vaz PD, Fernandes AC, Ferreira P, Romao C, Calhorda MJ, Eur. J.Pharm. Biopharm., 66, 357 (2007)

[34] Vallet-Regi M, Balas F, Arcos D, Angew. Chem. Int. Ed., 46, 7548 (2007)