전자빔을 이용한 폴록사머 하이드로젤의 제조 및 구강 점막부착성 약물전달을 위한 특성 분석

백은정; 신백기; 노영창; 임윤묵; 박종석; 박정숙; 허강무; Eun Jung Baek; Baek-Ki Shin; Young-Chang Nho; Youn-Mook Lim; Jong-Seok Park; Jeong-Sook Park; Kang Moo Huh

Polymer(Korea), Vol.36, No.2, 182-189, March, 2012

Export Citation

전자빔을 이용한 폴록사머 하이드로젤의 제조 및 구강 점막부착성 약물전달을 위한 특성 분석

Preparation of Poloxamer-based Hydrogels Using Electron Beam and Their Evaluation for Buccal Mucoadhesive Drug Delivery

백은정, 신백기¹, 노영창 ², 임윤묵², 박종석², 박정숙^{1, †}, 허강무 ^†

충남대학교 고분자공학과
¹충남대학교 약학대학
²한국원자력연구원 정읍방사선과학연구소 방사선공업환경연구부

Eun Jung Baek, Baek-Ki Shin¹, Young-Chang Nho², Youn-Mook Lim², Jong-Seok Park², Jeong-Sook Park^{1, †}, and Kang Moo Huh^†

Department of Polymer Science and Engineering, Chungnam National University, Daejeon 305-764, Korea
¹College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea
²Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 1266 Sinjeong-dong, Jeongeup-si, Jeollabuk-do 580-185, Korea

E-mail:,

초록

본 연구에서는 전자빔을 이용하여 폴록사머 하이드로젤을 제조하여 구강 점막부착성 약물전달체로서의 특성을 평가하고자 하였다. 온도감응성을 나타내는 폴록사머 고분자의 말단에 가교반응을 위한 비닐기를 도입한 후, 방사선 가교반응을 이용하여 하이드로젤을 제조하였다. 점착성 향상을 위한 첨가제로 점착성 고분자인 카보폴을 첨가하여 하이드로젤을 제조하였고, 카보폴이 점막부착성과 서방성 방출에 미치는 영향을 알아보았다. 결과적으로, 폴록사머 고분자의 말단 개질과 카보폴의 첨가에 의해 하이드로젤의 기계적 물성과 점막부착성이 향상되었고, 약물방출실험 결과 약물이 방출되는 속도가 지연되는 결과를 확인하였다.

In this study, poloxamer hydrogels were prepared by electron beam irradiation and evaluated for potential application as a buccal mucoadhesive drug delivery system. Poloxamer, one of typical thermoresponsive polymers, was modified to have vinyl end groups for crosslinking reaction, and its hydrogels were fabricated by irradiation crosslinking reaction. Carbopol as a mucoadhesive polymeric additive was introduced to improve the mucoadhesive property of the hydrogels and its effect on the mucoadhesion and drug release properties was investigated. The results showed that the end group modification of poloxamer and the addition of carbopol improved mucoadhesive force and mechanical properties and led to a sustained drug release behavior.

Keywords:hydrogel;mucoadhesion;poloxamer;carbopol;sustained release.

[References]

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Salamat-Miller N, Chittchang M, Johnston TP, Adv.Drug Deliver. Rev., 57, 1556 (2005)
Robinson JR, Longer MA, Veillard M, Ann. Ny.Acad. Sci., 507, 307 (1987)
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Duchene D, Touchard F, Peppas NA, Drug Dev. Ind.Pharm., 14, 283 (1988)
Robert C, Buri P, Peppas NA, Acta Pharm. Technol., 34, 95 (1988)
Devries ME, Bodde HE, Verhoef JC, Junginger HE, Crit. Rev. Ther. Drug., 8, 271 (1991)
Squier CA, Crit. Rev. Oral Biol. M., 2, 13 (1991)
Hennink WE, van Nostrum CF, Adv. Drug Deliver. Rev., 54, 13 (2002)
Omidian H, Rocca JG, Park K, J. Control. Release., 102, 3 (2005)
Kopecek J, Biomaterials., 28, 5185 (2007)
Smart JD, Adv. Drug Deliver. Rev., 57, 1556 (2005)
Wang PL, Johnston TP, Int. J. Pharm., 113, 73 (1995)
Fusco S, Borzacchiello A, Netti PA, J. Bioact. Compat. Pol., 21, 149 (2006)
Alexandridis P, Hatton TA, Colloid Surface A., 96, 1 (1995)
Han YK, Kwon JW, Kim JS, Cho CS, Wee WR, Lee JH, Brit. J. Ophthalmol., 87, 1399 (2003)
Chung HJ, Lee YH, Park TG, J. Control. Release., 127, 22 (2008)
Malmsten M, Soft Matter., 2, 760 (2006)
Morikawa K, Okada F, Hosokawa M, Kobayashi H, Cancer Res., 47, 37 (1987)
Bhardwaj R, Blanchard J, J. Pharm. Sci., 85, 915 (1996)
Desai SD, Blanchard J, J. Pharm. Sci., 87, 1190 (1998)
Lee JB, Chun KW, Yoon JJ, Park TG, Macromol. Biosci., 4, 957 (2004)
Chun KW, Lee JB, Kim SH, Park TG, Biomaterials., 26, 3319 (2005)
Kweon HY, Yoo MK, Lee JH, Wee WR, Han YG, Lee KG, Cho CS, J. Appl. Polym. Sci., 88(11), 2670 (2003)
Lugao AB, Malmonge SM, Nucl. Instrum. Meth. B., 185, 37 (2001)
Choi JH, Lee YJ, Lim YM, Kang PH, Shin J, Nho YC, Polym. Sci. Technol., 18(3), 253 (2007)
Jo SY, Lim YM, Youn MH, Gwon HJ, Park JS, Nho YC, Shin H, Polymer(Korea)., 33, 551 (2000)
Han IS, Lim YM, Gwon HJ, Park JS, Nho YC, Polym.(Korea), 35(1), 13 (2011)

[Referenced By]

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[1] Kim JS, Han K, J. Pharm. Invest., 32, 1 (2002)

[2] Salamat-Miller N, Chittchang M, Johnston TP, Adv.Drug Deliver. Rev., 57, 1556 (2005)

[3] Robinson JR, Longer MA, Veillard M, Ann. Ny.Acad. Sci., 507, 307 (1987)

[4] Leung SHS, Robinson JR, J. Control. Release., 12, 187 (1990)

[5] Park H, Robinson JR, Pharm. Res., 4, 457 (1987)

[6] Duchene D, Touchard F, Peppas NA, Drug Dev. Ind.Pharm., 14, 283 (1988)

[7] Robert C, Buri P, Peppas NA, Acta Pharm. Technol., 34, 95 (1988)

[8] Devries ME, Bodde HE, Verhoef JC, Junginger HE, Crit. Rev. Ther. Drug., 8, 271 (1991)

[9] Squier CA, Crit. Rev. Oral Biol. M., 2, 13 (1991)

[10] Hennink WE, van Nostrum CF, Adv. Drug Deliver. Rev., 54, 13 (2002)

[11] Omidian H, Rocca JG, Park K, J. Control. Release., 102, 3 (2005)

[12] Kopecek J, Biomaterials., 28, 5185 (2007)

[13] Smart JD, Adv. Drug Deliver. Rev., 57, 1556 (2005)

[14] Wang PL, Johnston TP, Int. J. Pharm., 113, 73 (1995)

[15] Fusco S, Borzacchiello A, Netti PA, J. Bioact. Compat. Pol., 21, 149 (2006)

[16] Alexandridis P, Hatton TA, Colloid Surface A., 96, 1 (1995)

[17] Han YK, Kwon JW, Kim JS, Cho CS, Wee WR, Lee JH, Brit. J. Ophthalmol., 87, 1399 (2003)

[18] Chung HJ, Lee YH, Park TG, J. Control. Release., 127, 22 (2008)

[19] Malmsten M, Soft Matter., 2, 760 (2006)

[20] Morikawa K, Okada F, Hosokawa M, Kobayashi H, Cancer Res., 47, 37 (1987)

[21] Bhardwaj R, Blanchard J, J. Pharm. Sci., 85, 915 (1996)

[22] Desai SD, Blanchard J, J. Pharm. Sci., 87, 1190 (1998)

[23] Lee JB, Chun KW, Yoon JJ, Park TG, Macromol. Biosci., 4, 957 (2004)

[24] Chun KW, Lee JB, Kim SH, Park TG, Biomaterials., 26, 3319 (2005)

[25] Kweon HY, Yoo MK, Lee JH, Wee WR, Han YG, Lee KG, Cho CS, J. Appl. Polym. Sci., 88(11), 2670 (2003)

[26] Lugao AB, Malmonge SM, Nucl. Instrum. Meth. B., 185, 37 (2001)

[27] Choi JH, Lee YJ, Lim YM, Kang PH, Shin J, Nho YC, Polym. Sci. Technol., 18(3), 253 (2007)

[28] Jo SY, Lim YM, Youn MH, Gwon HJ, Park JS, Nho YC, Shin H, Polymer(Korea)., 33, 551 (2000)

[29] Han IS, Lim YM, Gwon HJ, Park JS, Nho YC, Polym.(Korea), 35(1), 13 (2011)