Regioselective Surface Modification of PDMS Microfluidic Device for the Generation of Monodisperse Double Emulsions

Sora Hwang; Chang-Hyung Choi; Chang-Soo Lee

Macromolecular Research, Vol.20, No.4, 422-428, April, 2012

DOI10.1007/s13233-012-0048-8 Export Citation

Regioselective Surface Modification of PDMS Microfluidic Device for the Generation of Monodisperse Double Emulsions

Sora Hwang, Chang-Hyung Choi, and Chang-Soo Lee^†

Department of Chemical Engineering, Chungnam National University, Daejeon, 305-764, Korea

E-mail:

This study presents simple method for surface modification of hydrophobic poly(dimethylsiloxane) (PDMS) microchannel using combination of silane coupling and photopolymerization. The method spatially modulates the wettability and can fabricate high contrast spatial patterning of microfluidic device wettability. The physical and chemical characteristics are investigated with contact angle, Fourier-transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), change of meniscus of water fluid, and spatially selective immobilization of fluorescent dyes. We successfully use our method to selectively modify the surface properties in certain areas of assembled microchannel. Furthermore, our approach allows for the generation of highly monodisperse double emulsions and multiple emulsions containing various numbers of inner droplets.

Keywords:microfluidics;double emulsion;photopolymerization;monodispersity;wettability.

[References]

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Shim HW, Lee JH, Hwang TS, Rhee YW, Bae YM, Choi JS, Han J, Lee CS, Angew. Chem. Int. Ed., 46, 5408 (2007)
Jung JH, Choi CH, Chung S, Chung YM, Lee CS, Lab Chip., 9, 2596 (2009)
Shim HW, Lee CH, Lee JH, Hwang TS, Lee CS, J. Phys. Chem. Solids., 69, 1581 (2008)
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Abate AR, Lee D, Do T, Holtze C, Weitz DA, Lab Chip., 8, 516 (2008)
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Hu S, Ren X, Bachman M, Sims CE, Li GP, Allbritton N, Anal. Chem., 74, 4117 (2002)
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Barbier V, Tatoulian M, Li H, Arefi-Khonsari F, Ajdari A, Tabeling P, Langmuir, 22(12), 5230 (2006)
Parry KL, Shard AG, Short RD, Whie RG, Whittle JD, Wright A, Surf. Interface Anal., 38, 1497 (2006)
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Kim SH, Hwang H, Lim CH, Shim JW, Yang SM, Adv. Funct. Mater., 21(9), 1608 (2011)
Lee D, Weitz DA, Small., 5, 1932 (2009)

[Referenced By]

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[3] Nakashima T, Shimizu M, Kukizaki M, Adv. Drug Deliv. Rev., 45, 47 (2000)

[4] Solans C, Izquierdo P, Nolla J, Azemar N, Celma MJG, Curr. Opin. Colloid Interface Sci., 10, 102 (2005)

[5] Anna SL, Ontoux NB, Stone HA, Appl. Phys. Lett., 82, 364 (2003)

[6] Choi CH, Jung JH, Hwang TS, Lee CS, Macromol. Res., 17(3), 163 (2009)

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[8] Whitesides GM, Ostuni E, Takayama S, Jiang XY, Ingber DE, Annu. Rev. Biomed. Eng., 3, 335 (2001)

[9] McDonald JC, Duffy DC, Anderson JR, Chiu DT, Wu HK, Schueller OJA, Whitesides GM, Electrophoresis, 21(1), 27 (2000)

[10] McDonald JC, Whitesides GM, Acc. Chem. Res., 35, 291 (2002)

[11] Shim HW, Lee JH, Kim BY, Son YA, Lee CS, J.Nanosci. Nanotechnol., 9, 1204 (2009)

[12] Kim BY, Hong LY, Chung YM, Kim DP, Lee CS, Adv. Funct. Mater., 19(23), 3796 (2009)

[13] Shim HW, Lee JH, Hwang TS, Rhee YW, Bae YM, Choi JS, Han J, Lee CS, Angew. Chem. Int. Ed., 46, 5408 (2007)

[14] Jung JH, Choi CH, Chung S, Chung YM, Lee CS, Lab Chip., 9, 2596 (2009)

[15] Shim HW, Lee CH, Lee JH, Hwang TS, Lee CS, J. Phys. Chem. Solids., 69, 1581 (2008)

[16] Cho J, Kim S, Char K, Korean J. Chem. Eng., 20(1), 174 (2003)

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[19] Schneider MH, Willaime H, Tran Y, Rezgui F, Tabeling P, Anal. Chem., 82, 8848 (2010)

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[30] Bell J, Haycock J, Eur. Cell Mater., 22, 23 (2011)

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