State observability and observer designs are investigated for linear-time-invariant systems in continuous time when the outputs are measured only at a set of irregular sampling time sequences. The problem is primarily motivated by systems with limited sensor information in which sensor switching generates irregular sampling sequences. State observability may be lost and the traditional observers may fail in general, even if the system has a full-rank observability matrix. It demonstrates that if the original system is observable, the irregularly sampled system will be observable if the sampling density is higher than some critical frequency, independent of the actual time sequences. This result extends Shannon's sampling theorem for signal reconstruction under periodic sampling to system observability under arbitrary sampling sequences. State observers and recursive algorithms are developed whose convergence properties are derived under potentially dependent measurement noises. Persistent excitation conditions are validated by designing sampling time sequences. By generating suitable switching time sequences, the designed state observers are shown to be convergent in mean square, with probability one, and with exponential convergence rates. Schemes for generating desired sampling sequences are summarized.