Inorganic Chemistry, Vol.38, No.23, 5449-5452, 1999
Ionizable calixarene-crown ethers with high selectivity for radium over light alkaline earth metal ions
Two new ionizable calixarene-crown ethers, p-tert-butylcalix[4]arene-crown-6-dicarboxylic acid (3) and p-tert-butylcalix[4]arene-crown-6-dihydroxamic acid (4) with preorganized ionophoric cavities, exhibit high selectivity for Ra-223 over lighter alkaline earth metal ions. The ionizable calixcrowns show promising binding properties for developing a Ra-223-based alpha-emitter radioimmunotherapy.
Keywords:SOLVENT-EXTRACTION;MONOCLONAL-ANTIBODIES;BIOLOGICAL-SYSTEMS;CATIONS;COMPLEXATION;ACID;RADIOIMMUNOTHERAPY;RADIONUCLIDES;CHLOROFORM;TRANSPORT