We report experimental evidence of a 20-40 % enhancement of the effective heat transfer coefficient for laminar flow of a partially miscible binary liquid-liquid mixture in a small diameter horizontal tube that obtains when phase separation occurs in the tube. A mixture of acetone-hexadecane is quenched into the two-phase region so as to induce spinodal decomposition. The heat transfer rate is enhanced by self-induced convective effects sustained by the free energy liberated during phase separation. The experimental heat transfer coefficients obtained when separation occurs are compared to the corresponding values predicted for flow of a hypothetic mixture with identical properties but undergoing separation. For such comparison, the energy balance equation must carefully take into account both the sensible heat and the excess enthalpy difference between the inlet and the outlet streams because our liquid-liquid binary mixture is a very asymmetric system with large excess enthalpies. The non-ideal mixture thermodynamic properties needed for the energy balance are obtained by an empirical procedure from the experimental data available in the literature for our mixture. The experimental setup and calculation procedure is tested by experiments performed using single-phase water flow and single-phase mixture flow (above the critical point). The convective heat transfer augmentation that results in the presence of liquid-liquid phase separation may be exploited in the cooling or heating of small scale systems where turbulent convection cannot be achieved. (C) 2011 Elsevier Ltd. All rights reserved.