The present article deals with the peristaltic flow of a Williamson fluid in an inclined asymmetric channel. The relevant equations have been modeled. Analysis has been carried out in the presence of velocity and thermal slip conditions. Expressions for stream function, temperature, pressure gradient and heat transfer coefficients are derived. The solutions are compared with the existing available results in a limiting sense. Numerical integration has been performed for pressure rise per wavelength. Plots are presented and analyzed for various embedded parameters into the problem. Comparison between the solutions is also shown. (C) 2011 Elsevier Ltd. All rights reserved.