The Bactigras (R) paraffin tulle coated with chlorhexidine is normally used for the treatment of donor-site wounds in burn patients who received split-thickness skin grafts in several centers. It has some disadvantages, such as adhesion to wound surfaces and pain from the irritation caused by this dressing. The Telfa AMD (R), a non-adherent wound dressing which consists of absorbent cotton fibers impregnated with polyhexamethylene biguanide enclosed in a sleeve of thermoplastic polymers, is a new option for donor-site wound care which causes less adherence to the wound. The purpose of this study was to compare clinical efficacy of these two dressings for the management of donor-site wounds. Thirty-two patients who received split-thickness skin grafts by donor site harvesting from the thigh were enrolled in this study and randomized into two groups receiving either the Bactigras (R) or the Telfa AMD (R) wound treatment. Re-epithelialization, pain, infection and cost-effectiveness analyses were compared between both groups. The results showed that there was no significant difference in age, area of donor sites or length of hospital stays between the groups (p > 0.05). However, the day of re-epithelialization (>= 90%) was significantly shorter in patients treated with the Telfa AMD (R) compared to the Bactigras (R) group (14.00 +/- 3.05 vs. 9.25 +/- 1.88 days for Bactigras (R) and Telfa AMD (R) groups, respectively, p < 0.001). The average pain score was also significantly lower in the Telfa AMD (R) group (1.57 +/- 0.55 vs. 4.70 +/- 1.16, p < 0.001). There was no difference in the cost of treatment between the groups (4.64 +/- 1.97 vs. 5.72 +/- 2.54 USD, p = 0.19). This study indicated that the Telfa AMD (R) was an effective dressing for the treatment of donor-site wounds.