Enhancement of Thermomechanical Properties of Poly(D,L-lactic-co-glycolic acid) and Graphene Oxide Composite Films for Scaffolds

Ok Ja Yoon; Il Yung Sohn; Duck Jin Kim; Nae-Eung Lee

Macromolecular Research, Vol.20, No.8, 789-794, August, 2012

DOI10.1007/s13233-012-0116-0 Export Citation

Enhancement of Thermomechanical Properties of Poly(D,L-lactic-co-glycolic acid) and Graphene Oxide Composite Films for Scaffolds

Ok Ja Yoon, Il Yung Sohn, Duck Jin Kim, and Nae-Eung Lee^†

School of Advanced Materials Science and Engineering, Sungkyunkwan University, Gyeonggi, 440-746, Korea

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Thermomechanical and surface chemical properties of composite films of poly(D,L-lactic-co-glycolic acid) (PLGA) were significantly improved by the addition of graphene oxide (GO) nanosheets as nanoscale fillers to the PLGA polymer matrix. Enhanced thermomechanical properties of the PLGA/GO (2 wt%) composite film, including an increase in the crystallization temperature and reduction in the weight loss, were observed. The tensile modulus of a composite film with increased GO fraction was presumably enhanced due to the strong chemical bonding between the GO nanosheets and the PLGA matrix. Enhanced hydrophilicity of the composite film due to the embedded GO nanosheets also improved the biocompatibility of the composite film. Improved thermomechanical properties and biocompatibility of the PLGA composite films embedded with GO nanosheets may be applicable to biomedical applications such as scaffolds.

Keywords:graphene oxide (GO) nanosheets;composite films;thermomechanical properties;scaffolds.

[References]

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[2] Fan H, Hu Y, Zhang C, Li X, Lv R, Qin L, Zhu R, AAPG Bull., 27, 4573 (2006)

[3] Kawazoe N, Inoue C, Tateishi T, Chen GP, Biotechnol. Prog., 26(3), 819 (2010)

[4] Jayasuriya AC, Ebraheim NA, J. Mater. Sci. Mater.Med., 20, 1637 (2009)

[5] Lee JJ, Lee SG, Park JG, Yang YI, Kim JK, Curr. Appl. Phys., 7S1, e37 (2007)

[6] Cho HH, Han DW, Matsumura K, Tsutsumi S, Hyon SH, Biomaterials., 29, 884 (2008)

[7] Roth CC, Pediatr. Res., 67, 509 (2010)

[8] Leung L, Chan C, Baek S, Naguib H, Biomed. Mater., 3, 025006 (2008)

[9] Lee JH, Park TG, Park HS, Lee DS, Lee YK, Yoon SC, Biomaterials., 24, 2773 (2003)

[10] Oh SH, Kang SG, Lee JH, J. Mater. Sci. Mater.Med., 17, 131 (2006)

[11] Armentano I, Dottori M, Fortunati E, Mattioli S, Kenny JM, Polym. Degrad. Stab., 95, 2126 (2010)

[12] Armentano I, Dottori EM, Puglia ED, Jose E, Kenny M, J. Mater. Sci. Mater. Med., 19, 2377 (2008)

[13] Huang KJ, Niu DJ, Sun JY, Han CH, Wu ZW, Li YL, Xiong XQ, Colloids Surf. B: Biointerfaces., 82, 543 (2010)

[14] Ang PK, Jaiswal M, Lim CHYX, Wang Y, Sankaran J, Li A, Lim CT, Wohland T, Barbaros O, Loh KP, ACS Nano., 4, 7387 (2010)

[15] Ryoo SR, Kim YK, Kim MH, Min DH, ACS Nano., 4, 6587 (2010)

[16] Paredes JI, Villar-Rodil S, Martinez-Alonso A, Tascon JMD, Langmuir, 24(19), 10560 (2008)

[17] Kim H, Abdala AA, Macosko CW, Macromolecules, 43(16), 6515 (2010)

[18] Ryoo SR, Kim YK, Kim MH, Min DH, ACS Nano., 4, 6587 (2010)

[19] Agarwal S, Zhou XZ, Ye F, He QY, Chen GCK, Soo J, Boey F, Zhang H, Chen P, Langmuir, 26(4), 2244 (2010)

[20] Park S, Mohanty N, Suk JW, Nagaraja A, An JH, Piner RD, Cai WW, Dreyer DR, Berry V, Ruoff RS, Adv. Mater., 22(15), 1736 (2010)

[21] Park S, An J, Piner RD, Jung I, Yang D, Velamakanni A, Nguyen ST, Rouff RS, Chem. Mater., 20, 6592 (2008)

[22] Kaelble DH, J. Adhes., 2, 66 (1970)

[23] Lin C, Wang Y, Lai Y, Yang W, Jiao F, Zhang H, Ye S, Zhang Q, Macromol. Mater. Eng., 294, 666 (2009)

[24] Yoon OJ, Jung CY, Sohn IY, Kim HJ, Hong B, Jhon MS, Lee NE, Compos. Part A., 42, 1978 (2011)

[25] Chou WJ, Wang CC, Chen CY, Compos. Sci. Technol., 68, 2208 (2008)

[26] Kuila T, Bose S, Hong CE, Uddin ME, Khanra P, Kim NH, Lee JH, Carbon., 49, 1033 (2011)

[27] Noel M, Santhanam R, J. Power Sources, 72(1), 53 (1998)

[28] Patole AS, Patole SP, Kang H, Yoo JB, Kim TH, Ahn JH, J. Colloid Interface Sci., 350(2), 530 (2010)

[29] Chaisri W, Hennink WE, Ampasavate C, Okonogi S, AAPS PharmSciTech., 11, 945 (2010)

[30] Yang X, Tu Y, Li L, Shang S, Tao XM, ACS Appl.Mater. Interfaces., 2, 1707 (2010)

[31] Liu LQ, Barber AH, Nuriel S, Wagner HD, Adv. Funct. Mater., 15(6), 975 (2005)

[32] Penco M, Sartore L, Bignotti F, D'Antone S, Landro LD, Eur. Polym. J., 36, 901 (2000)

[33] Armentano I, Dottori M, Puglia D, Kenny JM, J.Mater. Sci. Mater. Med., 19, 2377 (2008)

[34] Wang R, Sun J, Gao L, Xu C, Zhang J, Chem. Commun., 47, 8650 (2011)

[35] Aboutalebi SH, Chidembo AT, Salari M, Konstantinov K, Wexler D, Liu HK, Dou S, Energy Environ. Sci., 4, 1855 (2011)

[36] Paredes JI, Villar-Rodil S, Martinez-Alonso A, Tascon JMD, Langmuir, 24(19), 10560 (2008)

[37] Jung M, El-Said WA, Choi JW, Nanotechnology., 22, 1 (2011)