Journal of Microencapsulation, Vol.27, No.3, 218-225, 2010
Chitosan derivative nanocarrier: Safety evaluation, antibacterial property and ascorbyl palmitate encapsulation
A chitosan derivative, methyl ether-terminated poly(ethylene oxide)-4-methoxycinnamolyphthaloylchitosan (PCPLC) was prepared, characterized and self-assembled into nanoparticles. Encapsulation of ascorbyl palmitate (AP) into PCPLC gave 689 +/- 0.98 nm particles with encapsulation efficiency of 84% at 56% drug loading. The encapsulated AP showed significant improved stability as examined by