Biofluids which exhibit non-Newtonian behavior are widely used in microfluidic devices which involve fluid mixing in microscales. In order to study the effects of shear depending viscosity of non-Newtonian fluids on characteristics of electroosmotic micromixing, a numerical investigation of flow of power-law fluid in a two-dimensional microchannel with nonuniform zeta potential distributions along the channel walls was carried out via finite volume scheme. The simulation results confirmed that the shear depending viscosity has a significant effect on the degree of mixing efficiency. It was shown as the fluid behavior index of power-law fluid, n, decreases, more homogeneous solution can be achieved at the microchannel outlet. Hence, electroosmotic micromixing was found more practical and efficient in microscale mixing of pseudoplastic fluids rather than those Newtonian and dilatant ones. Furthermore, it was found that increase in Reynolds number results in lower mixing efficiency while electroosmotic forces are kept constant. (C) 2011 Elsevier B.V. All rights reserved.