The influence of the degree of saturation (DOS) of a gas in a solution on the intensity of multibubble sonoluminescence (MBSL) excited by ultrasound with a frequency of 261 kHz, is investigated at various ultrasonic powers and with different concentrations of ethanol, which is added as a volatile solute. At relatively low powers and a high DOS, low ethanol concentrations give higher sonoluminescence (SL) intensities than those obtained with pure water. This intensity enhancement decreases as sonication proceeds because the SL intensity for pure water increases with time, whereas it remains almost constant or decreases slightly in solutions containing ethanol. At relatively low powers, a partially degassed solution has a higher SL intensity than a solution with a high DOS for both pure water and solutions containing ethanol. The reason Why the DOS decreases more when ethanol is added is considered mainly to be the accumulation of hydrocarbon products and the promotion of rectified diffusion. Adding an alcohol to a solution enhances ultrasonic degassing.