Separation of a high-value pharmaceutical compound from waste ethanol by nanofiltration

M. Brito Martı´nez; B. Van der Bruggen; Z. Rodriguez Negrin; P. Luis Alconero

Journal of Industrial and Engineering Chemistry, Vol.18, No.5, 1635-1641, September, 2012

DOI10.1016/j.jiec.2012.02.024 Export Citation

Separation of a high-value pharmaceutical compound from waste ethanol by nanofiltration

M. Brito Martı´nez^†, B. Van der Bruggen¹, Z. Rodriguez Negrin, and P. Luis Alconero¹

Center of Bioactive Chemicals Universidad Central ‘‘Marta Abreu’’ de Las Villas, Road to Camajuanı´ km 51/2, Villa Clara, Cuba
¹Department of Chemical Engineering, Laboratory for Applied Physical Chemistry and Environmental Technology, K.U. Leuven, W. de Croylaan 46, B-3001 Leuven, Belgium

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Recovery of the high-value active pharmaceutical ingredient 1-(5-bromo-fur-2-il)-2-bromo-2- nitroethane, referred as G-1 in this work, from ethanol solution was studied by using nanofiltration (NF), with the objective of closing the production cycle. A recovery of G-1 around 90% was obtained, offering the self-made membranes with 25% and 27% PES and the commercial membrane NF270 (FilmTec, Dow) the most promising results in terms of flux of ethanol through the membrane. These membranes were considered in the process design of a real scale system, showing the technical and economic viability of NF for G-1 recovery.

Keywords:API recovery;Cross-flow nanofiltration;Membrane synthesis;Pharmaceutical production

[References]

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Van der Bruggen B, Schaep J, Maes W, Wilms D, Vandecasteele C, Desalination, 117(1-3), 139 (1998)
Tsuru T, Sudou T, Kawahara S, Yoshioka T, Asaeda M, J. Colloid Interface Sci., 228(2), 292 (2000)
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Tarleton ES, Robinson JP, Millington CR, Nijmeijer A, J. Membr. Sci., 252(1-2), 123 (2005)
Nair D, Scarpello JT, White LS, Freitas dos Santos LM, Vankelecom IFJ, Livingston AG, Tetrahedr. Lett., 42(46), 8219 (2001)
Boussu K, De Baerdemaeker J, Dauwe C, Depla D, Aldea S, Vankelecom IFJ, Vandecasteele C, Van der Bruggen B, Physico-chemical characterization of nanofiltration membranes, Chem. Phys. Chem., 8(3), 370 (2007)
Ebert K, Cuperus FP, Membr. Technol., 107 (1999)
Desai DC, Mehta MH, Dave AN, Mehta JN, Ind. J. Chem. Technol., 9(6), 529 (2002)
Raman LP, Cheryan M, Rajagopalan N, JAOCS., 73, 219 (1996)
Machado DR, Hasson D, Semiat R, J. Membr. Sci., 163(1), 93 (1999)
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Whu JA, Baltzis BC, Sirkar KK, J. Membr. Sci., 163(2), 319 (1999)
Van der Bruggen B, Schaep J, Wilms D, Vandecasteele C, J. Membr. Sci., 156(1), 29 (1999)
Peters M, Timmerhaus K, Plant Design and Economics for Chemical Engineers, 3rd edition, McGraw Hill, New York, 435 (2003)
See-Toh YH, Ferreira FC, Livingston AG, J. Membr. Sci., 299(1-2), 236 (2007)
Boussu K, Vandecasteele C, Van der Bruggen B, Polymer, 47(10), 3464 (2006)
Ismail AF, Lai PY, Sep. Purif. Technol., 33, 127 (2004)
Kim IC, Yoon HG, Lee KH, J. Appl. Polym. Sci., 84(6), 1300 (2002)
Hicke HG, Lehmann I, Malsch G, Ulbricht M, Becker M, J. Membr. Sci., 198(2), 187 (2002)
Dai Y, Jian XG, Zhang SH, Guiver MD, J. Membr. Sci., 188(2), 195 (2001)

[1] Geens J, De Witte B, Van der Bruggen B, Removal of API’s (Active Pharmaceutical Ingredients) from organic solvents by nanofiltration, Separ. Sci. Technol., 42(42), 2435 (2007)

[2] Mulder M, Basic Principles of Membrane Technology, 2nd edition, Kluwer Academic Publishers, Dordrecht, 71 (2004)

[3] Cuperus P, Ebert K, Non-aqueous applications of NF, in: Nanofiltration Principles and Applications, Oxford, Elsevier Advanced Technology (Chapter 21)., 521 (2002)

[4] Van der Bruggen B, Schaep J, Maes W, Wilms D, Vandecasteele C, Desalination, 117(1-3), 139 (1998)

[5] Tsuru T, Sudou T, Kawahara S, Yoshioka T, Asaeda M, J. Colloid Interface Sci., 228(2), 292 (2000)

[6] Whu JA, Baltzis BC, Sirkar KK, J. Membr. Sci., 170(2), 159 (2000)

[7] Yang XJ, Livingston AG, dos Santos LF, J. Membr. Sci., 190(1), 45 (2001)

[8] Tarleton ES, Robinson JP, Millington CR, Nijmeijer A, J. Membr. Sci., 252(1-2), 123 (2005)

[9] Nair D, Scarpello JT, White LS, Freitas dos Santos LM, Vankelecom IFJ, Livingston AG, Tetrahedr. Lett., 42(46), 8219 (2001)

[10] Boussu K, De Baerdemaeker J, Dauwe C, Depla D, Aldea S, Vankelecom IFJ, Vandecasteele C, Van der Bruggen B, Physico-chemical characterization of nanofiltration membranes, Chem. Phys. Chem., 8(3), 370 (2007)

[11] Ebert K, Cuperus FP, Membr. Technol., 107 (1999)

[12] Desai DC, Mehta MH, Dave AN, Mehta JN, Ind. J. Chem. Technol., 9(6), 529 (2002)

[13] Raman LP, Cheryan M, Rajagopalan N, JAOCS., 73, 219 (1996)

[14] Machado DR, Hasson D, Semiat R, J. Membr. Sci., 163(1), 93 (1999)

[15] Machado DR, Hasson D, Semiat R, J. Membr. Sci., 166(1), 63 (2000)

[16] Whu JA, Baltzis BC, Sirkar KK, J. Membr. Sci., 163(2), 319 (1999)

[17] Van der Bruggen B, Schaep J, Wilms D, Vandecasteele C, J. Membr. Sci., 156(1), 29 (1999)

[18] Peters M, Timmerhaus K, Plant Design and Economics for Chemical Engineers, 3rd edition, McGraw Hill, New York, 435 (2003)

[19] See-Toh YH, Ferreira FC, Livingston AG, J. Membr. Sci., 299(1-2), 236 (2007)

[20] Boussu K, Vandecasteele C, Van der Bruggen B, Polymer, 47(10), 3464 (2006)

[21] Ismail AF, Lai PY, Sep. Purif. Technol., 33, 127 (2004)

[22] Kim IC, Yoon HG, Lee KH, J. Appl. Polym. Sci., 84(6), 1300 (2002)

[23] Hicke HG, Lehmann I, Malsch G, Ulbricht M, Becker M, J. Membr. Sci., 198(2), 187 (2002)

[24] Dai Y, Jian XG, Zhang SH, Guiver MD, J. Membr. Sci., 188(2), 195 (2001)