Although dual-fuel (DF) engines using a low cetane number primary fuel such as natural gas (NG) ignited by a pilot diesel spray have been the subject of much investigation over years, there are still many unknown problems related to the fundamental combustion process of two fuels. In this work, a quiescent constant volume combustion bomb and a 3-D numerical model have been used to study the effects of injection nozzle characteristics on the combustion of pre-mixed NG/air with pilot distillate spray. Experimental tests were conducted on combustion process of pre-mixed natural gas/air with pilot injection pressure of 30 and 20 MPa with a 4 hole injector, and also with injector nozzle of 8 and 4 holes. The global results obtained from computations compared well with the experimental results.