Journal of the American Chemical Society, Vol.133, No.17, 6517-6520, 2011
A More Comprehensive and Highly Practical Solution to Enantioselective Aldehyde Crotylation
The enantioselective crotylation of aldehydes with 1,2-diaminochlorocrotylsilane reagents is effectively catalyzed by Sc(OTf)(3). The one significant limitation on the utility of these reagents - substrate scope - has thus been addressed. The net result is the most comprehensive and highly practical method for enantioselective aldehyde crotylation yet advanced.