Journal of the American Chemical Society, Vol.133, No.18, 6918-6921, 2011
Rhodium-Catalyzed Enantioselective Cyclizations of gamma-Alkynylaldehydes with Acyl Phosphonates: Ligand- and Substituent-Controlled C-P or C-H Bond Cleavage
It has been established that a cationic rhodium(I)/(R)-H(8)-BINAP or (R)-Segphos complex catalyzes two modes of enantioselective cyclizations of gamma-alkynylaldehydes with acyl phosphonates via C-P or C-H bond cleavage. The ligands of the Rh(I) complexes and the substitutents of both gamma-alkynylaldehydes and acyl phosphonates control these two different pathways.