Journal of the American Chemical Society, Vol.133, No.25, 9727-9729, 2011
Total Synthesis of the Cyanolide A Aglycon
The synthesis of the potent molluscicide cyanolide A has been achieved in 10 steps without the use of protecting groups. The synthesis features a key Sakurai macrocyclization/dimerization reaction that simultaneously forms both tetrahydropyran rings and the macrocycle of the natural product.