Expedient Synthesis of N-Acyl Anthranilamides and beta-Enamine Amides by the Rh(III)-Catalyzed Amidation of Aryl and Vinyl C-H Bonds with Isocyanates

Hesp KD; Bergman RG; Ellman JA

Journal of the American Chemical Society, Vol.133, No.30, 11430-11433, 2011

DOI10.1021/ja203495c Export Citation

Expedient Synthesis of N-Acyl Anthranilamides and beta-Enamine Amides by the Rh(III)-Catalyzed Amidation of Aryl and Vinyl C-H Bonds with Isocyanates

Hesp KD, Bergman RG, Ellman JA

A Rh(III)-catalyzed protocol for the amidation of anilide and enamide C H bonds with isocyanates has been developed. This method provides direct and efficient syntheses of N-acyl anthranilamides, enamine amides, and pyrimidin-4-one heterocycles.