Nitrogen Kinetic Isotope Effects for the Monoamine Oxidase B-Catalyzed Oxidation of Benzylamine and (1,1-H-2(2))Benzylamine: Nitrogen Rehybridization and CH Bond Cleavage Are Not Concerted

MacMillar S; Edmondson DE; Matsson O

Journal of the American Chemical Society, Vol.133, No.32, 12319-12321, 2011

DOI10.1021/ja205629b Export Citation

Nitrogen Kinetic Isotope Effects for the Monoamine Oxidase B-Catalyzed Oxidation of Benzylamine and (1,1-H-2(2))Benzylamine: Nitrogen Rehybridization and CH Bond Cleavage Are Not Concerted

MacMillar S, Edmondson DE, Matsson O

Nitrogen kinetic isotope effects for the oxidation of benzylamine and (1,1-H-2(2))benzylamine by recombinant human monoamine oxidase B show that cleavage of the CH bond is not concerted with rehybridization of the nitrogen atom.