화학공학소재연구정보센터
Journal of the American Chemical Society, Vol.133, No.40, 15902-15905, 2011
Palladium-Catalyzed Regio- and Enantioselective Fluorination of Acyclic Allylic Halides
This report describes the Pd(0)-catalyzed fluorination of linear allylic chlorides and bromides, yielding branched allylic fluorides in high selectivity. Many of the significant synthetic limitations previously associated with the preparation of these products are overcome by this catalytic method. We also demonstrate that a chiral bisphosphine-ligated palladium catalyst enables highly enantioselective access to a class of branched allylic fluorides that can be readily diversified to valuable fluorinated products.