Journal of the American Chemical Society, Vol.134, No.6, 2852-2855, 2012
Transcription Regulation System Mediated by Mechanical Operation of a DNA Nanostructure
A transcription regulation system initiated by DNA nanostructure changes was designed and constructed. Using the toehold system, specific DNA strands induced the opening of the tubular structure. A transcription product from the purified tube-attached dsDNA template was observed by addition of DNA strands that were specific for opening the tubular structure.