Synthetic Polymer Nanoparticles Conjugated with FimH(A) from E. coli Pili to Emulate the Bacterial Mode of Epithelial Internalization

Lin LY; Tiemann KM; Li Y; Pinkner JS; Walker JN; Hultgren SJ; Hunstad DA; Wooley KL

Journal of the American Chemical Society, Vol.134, No.9, 3938-3941, 2012

DOI10.1021/ja2091917 Export Citation

Synthetic Polymer Nanoparticles Conjugated with FimH(A) from E. coli Pili to Emulate the Bacterial Mode of Epithelial Internalization

Lin LY, Tiemann KM, Li Y, Pinkner JS, Walker JN, Hultgren SJ, Hunstad DA, Wooley KL

Amphiphilic block copolymer nanoparticles are conjugated with uropathogenic Escherichia coli type 1 pilus adhesin FimH(A) through amidation chemistry to enable bladder epithelial cell binding and internalization of the nanoparticles in vitro.