The influences of channel orientation and wall heating condition on the local surface heat transfer coefficient in a rotating, two-pass, square channel with 60 degrees and 90 degrees ribs on the leading and trailing walls were investigated for Reynolds numbers from 2500 to 25000 and rotation numbers from 0 to 0.352. The two channel orientations were (1) square channel perpendicular to the axis of rotation and (2) square channel twisted at 45 degrees to the axis of rotation. Two thermal boundary condition cases were studied : (A) all four walls at the same temperature and (B) all four walls at the same heat flux. Results show the Coriolis force effect is reduced for the 45 degrees channel orientation. Thus, heat transfer coefficients decrease for the first pass trailing and second pass leading walls and increase for the first pass leading and second pass trailing walls, compared with their corresponding perpendicular channel orientation values. The increase of heat transfer coefficients for uneven wall heating condition Case (B) when compared to their corresponding heat transfer coefficients for Case A is greater for the 45 degrees channel orientation than for the perpendicular channel orientation.