Chitosan nanocapsules are prepared using poly(S-co-MAA) particles as the template and cross-linked chitosan with glutaraldehyde as shell, the core templates are removed by THF. The template particles and nanocapsules are characterized by FESEM and TEM. By dissolution of ibuprofen in the chloroform droplets prepares the poly(S-co-MAA), drug-loaded nanocapsules are also fabricated. It is found that the loaded drug can be released again in a sustained manner for up to 80 h.