The hyperbranched polyurethane acrylate oligomers containing photoinitiator were synthesized by modifying the second-generation hyperbranched poly(amine-ester) with isophorone diisocyanate-2-hydroxyethylacrylate and isophorone diisocyanate-2-hydroxy-2-methylpropiophenone at different feed ratio. The elemental analysis, FT-IR and NMR methods are used for structural characterization, molecular weights, and polydispersities, photosensitive groups and thermal properties of the oligomers were analyzed by gel permeation chromatography, UV-Vis spectra and thermogravimetric analysis, respectively. UV-curing properties were characterized by FT-IR at different curing time. In addition, the solubilities of the oligomers were also examined.