The dilution enthalpies of N,N-dimethylformamide (DMF) in aqueous ethylene glycol and glycerol solutions have been determined using a CSC-4400 isothermal calorimeter at 298.15 K. The experimental data have been analyzed in terms of McMillan-Mayer formalism to obtain the enthalpic virial coefficients for heterotactic interaction. The results have been interpreted from the point of view of solute-solute interactions and solute-solvent interactions. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.