In acid fracturing, excessive acid leakoff is thought to be the main reason that limits fracture propagation and live acid penetration distance. Since most carbonates are naturally fractured, we developed a new model in this paper to simulate acid leakoff into a naturally fractured carbonate oil reservoir during acid fracturing. Our model incorporates the acid-rock reaction, fracture width variation due to rock dissolution on the fractured surfaces, and fluid flow in naturally fractured carbonate oil reservoirs. Given the information of the reservoir, injected acid, and pressure in the hydraulic facture and the reservoir, the model predicts acid leakoff with time. In this study, we found that acid leakoff mechanism in naturally fractured carbonates is much different from that in reservoirs without natural fractures. Widened natural fractures by acid-rock reaction act as high-conductivity conduits allowing leakoff acid to penetrate deeper into the formation, resulting in serious leakoff. Wide natural fractures have a dominant effect on acid leakoff compared to micro-fractures and matrix.