Based on the microscale temperature, the effective thermal conductivity in the principal direction of an anisotropic porous medium is evaluated. A correlation of the effective thermal conductivity then is employed to predict the volume-averaged temperature of a two-dimensional nonhomogeneous anisotropic porous medium. Through the example, the present model is found to possess an excellent performance even when the principal direction of the anisotropic medium is not parallel to the physical coordinates. The results also reveal that using the classic mixing rule could lead to a significant error when the thermal conductivity ratio of the solid and fluid is large. The present numerical procedure is believed to be able to determine the effective thermal conductivity for most porous media as long as their microstructure is regular and known.