C-reactive protein (CRP) is a highly conserved plasma protein belonging to pentraxins, a superfamily which has significant proinflammatory role. Therefore, CRP can be a good target for drug discovery to prevent disease pathogenesis, especially cardioprotection in acute myocardial infarction and neuroprotection in stroke. Hence, the knowledge of the structure of CRP is very important. In this paper, we have demonstrated three-dimensional structure, conserved domains, and surface structure of human CRP with the help of bioinformatics analysis. We have also depicted that evolutionary relationship of CRP exists among the different species. Simultaneously, WebLogo has been generated to know the more conserved part of this medically important protein.