Oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus. Excessively high levels of free radicals cause damage to cellular proteins, membrane lipids and nucleic acids, and eventually cell death. The present study was designed to investigate the possible effect of leaf extract in high fat diet induced diabetic Charles Foster rats. The increased level of lipidperoxidation and altered levels of enzymatic (superoxide dismutase, glutathione peroxidase and catalase) and non-enzymatic (glutathione) antioxidants were seen in high fructose fed animals. The treatment with leaf extract significantly normalized the altered levels of lipid peroxidation and antioxidant status at 400 mg/kg b.w. dose. The leaf extract was also tested for inhibition of generation of superoxide anion and hydroxyl free radical in both enzymatic and non-enzymatic systems. The leaf extract was found to inhibit generation of superoxide anion and hydroxyl free radical significantly at 200 mu g/ml concentration. Data of present study demonstrated that the leaf extract has both antidiabetic and antioxidant properties.