Applied Biochemistry and Biotechnology, Vol.167, No.3, 581-594, 2012
Synthesis, Characterization and Biological Evaluation of Fe (III), Co (II), Ni(II), Cu(II), and Zn(II) Complexes with Tetradentate Schiff Base Ligand Derived from Protocatechualdehyde with 2-Aminophenol
Schiff base ligand (H3L) was prepared from the condensation reaction of protochatechualdehyde (3,4-dihydroxybenzaldhyde)with 2-amino phenol. From the direct reaction of the ligand (H3L) with Co(II), Ni(II) and Cu(II) chlorides, and Fe(III)and Zn(II)nitrates in 2 M/1 L molar ratio, the five new neutral complexes were prepared. The characterization of the newly formed compounds was done by H-1 NMR, UV-Vis, and IR spectroscopy and elemental analysis. The in vitro antibacterial activity of the metal complexes was studied and compared with that of free ligand.