The problem of determining the trajectories to control greenhouse crop growth has traditionally been solved by using constrained optimization or applying artificial intelligence techniques. The economic profit has been used as the main criterion in most research on optimization to obtain adequate climatic control setpoints for the crop growth. This paper addresses the problem of greenhouse crop growth through a hierarchical control architecture governed by a high-level multiobjective optimization approach, where the solution to this problem is to find reference trajectories for diurnal and nocturnal temperatures (climate-related setpoints) and electrical conductivity (fertirrigation-related setpoints). The objectives are to maximize profit, fruit quality, and water-use efficiency, these being currently fostered by international rules. Illustrative results selected from those obtained in an industrial greenhouse during the last eight years are shown and described. (C) 2012 Elsevier Ltd. All rights reserved.