When highly exothermic/hazardous reactions are conducted in the presence of parametric uncertainty, derivation of optimal operating policies for a semibatch reactor has to simultaneously consider several objectives of sustainability. This paper presents a methodology to generate the Pareto optimal solutions when reactor productivity (product yield) and safety objectives (expressed in probabilistic terms) are simultaneously considered in a simple way, in the presence of technological constraints, uncertainty in safety boundaries, and random fluctuations in control variables. Exemplification is made for a semibatch reactor of high thermal sensitivity used for the catalytic acetoacetylation of pyrrole with diketene in homogeneous liquid phase.