The degradation of C.I. Acid Orange 7 by ozone combined with hydrogen peroxide was carried out in a hollow fiber membrane reactor, and batch recirculation mode of aqueous phase was employed. The effect of initial pH, hydroxyl radical scavenger, hydrogen peroxide concentration, liquid recirculation rate, gas flow rate, and gaseous ozone concentration on the decolorization of C.I. Acid Orange 7 was investigated. The results showed that the decolorization of C.I. Acid Orange 7 fits the pseudo-half-order kinetic model. The rate constant increased with the increase of initial pH, hydrogen peroxide concentration, liquid recirculation rate, gas flow rate, and gaseous ozone concentration. The presence of hydroxyl radical scavenger inhibited the decolorization rate by over 50%. The combination of ozone with hydrogen peroxide achieved a higher COD removal efficiency than ozone alone in the membrane reactor.