Dividing-wall column (DWC) is one of the best examples of process intensification, as it can bring significant reduction in the capital invested as well as savings in the operating costs. Conventional ternary separations progressed from the (in-)direct sequences to thermally coupled columns such as Petlyuk configuration, and later to the DWC compact design that integrates the two distillation columns into a single shell. Nevertheless, this integration leads also to changes in the control and operating mode due to the higher number of degrees of freedom. In this work we explore the dynamic optimization and advanced control strategies based on model predictive control (MPC), coupled or not with PID. These structures were enhanced by adding an extra loop controlling the heavy component in the top of the feed side of the column, using the liquid split as manipulated variable, thus implicitly achieving energy minimization. To allow a fair comparison with previously published references, this work considers as a case-study the industrially relevant separation of the mixture benzene-toluene-xylene (BTX) in a DWC. The results show that MPC leads to a significant increase in performance, as compared to previously reported conventional PID controllers within a multi-loop framework. Moreover, the optimization employed by the MPC efficiently accommodates the goal of minimum energy requirements - possible due to the addition of an extra loop - in a transient state. The practical benefits of coupling MPC with PID controllers are also clearly demonstrated. (C) 2011 Elsevier Ltd. All rights reserved.