Self-generating CO2 huff-and-puff technology involves injection of reagents into formations that react with each other to generate carbon dioxide. We demonstrate the feasibility of applying this technology in the late stage of Jiangsu oilfield development by flooding. We have studied the factors affecting oil recovery by the self-generating CO2 huff-and-puff (cyclic) approach and we have studied the mechanism for enhanced oil recovery. We show that the self-generating CO2 huff-and-puff technology followed by waterflooding is more efficient than waterflooding followed by self-generating CO2 huff-and-puff. Self-generating CO2 huff-and-puff is more effective in low-permeability reservoirs.