Chemistry Letters, Vol.40, No.12, 1440-1442, 2011
Stereoselective Synthesis of Allylsilanes Bearing Tetrasubstituted Olefin via 2,2-Diborylethylsilane
The regio- and stereoselective synthesis of allylsilane derivatives bearing a tetrasubstituted olefin was achieved using 2,2-diborylethylsilane as a key intermediate. The regioselective deprotonation of a 2,2-diborylethylsilane with LTMP and the subsequent nucleophilic addition to ketones gave corresponding allylsilanes in good to excellent yield with excellent stereoselectivity.