Chemistry Letters, Vol.41, No.5, 535-537, 2012
A Facile Synthesis of New 4-Amino-2-iminothiazoles from Unsymmetrical Thioureas
An efficient methodology for the synthesis of 4-amino-2-iminothiazole derivatives has been developed. The synthesis involves the cyclization of unsymmetrical 1-aroyl-3-arylthioureas with a variety of 2-bromo-2-phenylacetonitriles bearing alpha-H in the presence of triethylamine and acetonitrile.